29 research outputs found
Flexible Integration of Gigahertz Nanomechanical Resonators with a Superconducting Microwave Resonator using a Bonded Flip-Chip Method
We demonstrate strong coupling of gigahertz-frequency nanomechanical
resonators to a frequency-tunable superconducting microwave resonator via a
galvanically bonded flip-chip method. By tuning the microwave resonator with an
external magnetic field, we observe a series of hybridized microwave-mechanical
modes and report coupling strengths of at cryogenic
temperatures. The demonstrated multi-chip approach provides flexible rapid
characterization and simplified fabrication, and could potentially enable
coupling between a variety of quantum systems. Our work represents a step
towards a plug-and-play architecture for building more complex hybrid quantum
systems.Comment: 10 pages, 8 figures. First three authors contributed equally to this
wor
Single-Mode Squeezed Light Generation and Tomography with an Integrated Optical Parametric Oscillator
Quantum optical technologies promise advances in sensing, computing, and
communication. A key resource is squeezed light, where quantum noise is
redistributed between optical quadratures. We introduce a monolithic,
chip-scale platform that exploits the nonlinearity of a thin-film
lithium niobate (TFLN) resonator device to efficiently generate squeezed states
of light. Our system integrates all essential components -- except for the
laser and two detectors -- on a single chip with an area of one square
centimeter, significantly reducing the size, operational complexity, and power
consumption associated with conventional setups. Our work addresses challenges
that have limited previous integrated nonlinear photonic implementations that
rely on either nonlinear resonators or on integrated waveguide
parametric amplifiers. Using the balanced homodyne measurement
subsystem that we implemented on the same chip, we measure a squeezing of 0.55
dB and an anti-squeezing of 1.55 dB. We use 20 mW of input power to generate
the parametric oscillator pump field by employing second harmonic generation on
the same chip. Our work represents a substantial step toward compact and
efficient quantum optical systems posed to leverage the rapid advances in
integrated nonlinear and quantum photonics.Comment: 21 pages; 4 figures in main body, 8 supplementary figure
Strong dispersive coupling between a mechanical resonator and a fluxonium superconducting qubit
We demonstrate strong dispersive coupling between a fluxonium superconducting
qubit and a 690 megahertz mechanical oscillator, extending the reach of circuit
quantum acousto-dynamics (cQAD) experiments into a new range of frequencies. We
have engineered a qubit-phonon coupling rate of
, and achieved a dispersive interaction that
exceeds the decoherence rates of both systems while the qubit and mechanics are
highly nonresonant (). Leveraging this strong coupling, we
perform phonon number-resolved measurements of the mechanical resonator and
investigate its dissipation and dephasing properties. Our results demonstrate
the potential for fluxonium-based hybrid quantum systems, and a path for
developing new quantum sensing and information processing schemes with phonons
at frequencies below 700 MHz to significantly expand the toolbox of cQAD.Comment: 22 pages, 12 figure
III/V-on-lithium niobate amplifiers and lasers
We demonstrate electrically pumped, heterogeneously integrated lasers on thin-film lithium niobate, featuring electro-optic wavelength tunability. (C) 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreemen
Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis
Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological processes. Even though the ubiquitin system has been implicated in several human diseases, the role of ubiquitination in liver fibrosis remains poorly understood. Here, multi-omics approaches were used to address this. Untargeted metabolomics showed that carbon tetrachloride (CCl4)-induced liver fibrosis promotes changes in the hepatic metabolome, specifically in glycerophospholipids and sphingolipids. Gene ontology analysis of public deposited gene array-based data and validation in our mouse model showed that the biological process “protein polyubiquitination” is enriched after CCl4-induced liver fibrosis. Finally, by using transgenic mice expressing biotinylated ubiquitin (bioUb mice), the ubiquitinated proteome was isolated and characterized by mass spectrometry in order to unravel the hepatic ubiquitinated proteome fingerprint in CCl4-induced liver fibrosis. Under these conditions, ubiquitination appears to be involved in the regulation of cell death and survival, cell function, lipid metabolism, and DNA repair. Finally, ubiquitination of proliferating cell nuclear antigen (PCNA) is induced during CCl4-induced liver fibrosis and associated with the DNA damage response (DDR). Overall, hepatic ubiquitome profiling can highlight new therapeutic targets for the clinical management of liver fibrosis.This work was supported by grants from Gobierno Vasco-Departamento de Salud 2013111114 (to M.L.M.-C.), ELKARTEK 2016, Departamento de Industria del Gobierno Vasco (to M.L.M.-C.), Ministerio de Ciencia, Innovación y Universidades MICINN: SAF2017-87301-R, SAF2017-88041-R, RTI2018-096759-A-100 and SAF2016-76898-P integrado en el Plan Estatal de Investigación Cientifica y Técnica y Innovación, cofinanciado con Fondos FEDER (to M.L.M.-C., J.M.M., T.C.D. and U.M. respectively); AECC Bizkaia (M.S.-M.); Asociación Española contra el Cáncer (T.C.D.), Fundación Científica de la Asociación Española Contra el Cancer (AECC Scientific Foundation) Rare Tumor Calls 2017 (to M.L.M., J.M.B., M.A.A., J.J.G.M.), La Caixa Foundation Program (to M.L.M.), 2018 BBVA Foundation Grants for Scientific Research Teams (to M.L.M.-C.). This research was also funded by the CIBERehd (EHD15PI05/2016) and “Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III”, Spain (PI16/00598 and PI19/00819, co-funded by European Regional Development Fund/European Social Fund, “Investing in your future”); Spanish Ministry of Economy, Industry and Competitiveness (SAF2016-75197-R); “Junta de Castilla y Leon” (SA063P17); AECC Scientific Foundation (2017/2020), Spain; “Centro Internacional sobre el Envejecimiento” (OLD-HEPAMARKER, 0348_CIE_6_E), Spain; University of Salamanca Foundation, Spain (PC-TCUE18-20_051), and Fundació Marato TV3 (Ref. 201916-31), Spain (to J.J.G.M.). The UPV/EHU Lab and the Proteomics Platform are members of Proteored, PRB3 and is supported by grant PT17/0019, of the PE I + D + i 2013-2016, funded by ISCIII and ERDF. Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud Carlos III. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644)